Looks like you are in hybrid.
Does this apply?
https://learn.microsoft.com/en-us/office365/troubleshoot/ediscovery/cannot-run-ediscovery-search-cloud-mailbox
In-Place Discovery & Hold not work in Exchange 2013

Hi, I am Rubiat,
I have been facing an issue for 2/3 months. I couldn't understand how to fix it. Please see the below screenshot and please give me any suggestion to fix it. Thank you
2 answers
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Andy David - MVP 121K Reputation points MVP
2022-04-26T12:01:45.787+00:00 -
KyleXu-MSFT 25,866 Reputation points
2022-04-27T06:05:13.877+00:00 Mark sure Exchange 2013 is updated to the latest version: CU 23 + Mar22SU
Try to access the "https://localhost/ecp/?ExchClientVer=15" on Exchange server directly. It could help us to narrow down whether there exists issue network.
If there exists third-party antivirus software on your Exchange server, it is also suggested to uninstall it temporarily for checking whether network request block/limited by it.
Based on my searching, the issue may also relate to TLS 1.2, use the command below to check whether is it enabled on your Exchange server
[Net.ServicePointManager]::SecurityProtocol
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