Hi @Kumar ,
Thanks for reaching out to Q&A forum.
Throughput is affected by the number and rate of concurrent client connections, the kind and number of configured policies, payload sizes, backend API performance, and other factors. The numbers presented in the document were obtained by testing with 1000 concurrent persistent client secure HTTP connections, minimal payload sizes, no policies configured, and a low latency backend API.
So when a backend api is taking a long time to respond, it will affect the throughput of the APIM instance. Ideal way to deal with the backend latency is to optimize the performance of the backend api by caching, scaling, zone redundancy etc.
I hope this helps! Feel free to reach out to me if you have any queries or concerns.
Please 'Accept as answer' and ‘Upvote’ if it helped so that it can help others in the community looking for help on similar topics.