Hi There,
Thank you for asking this question on the Microsoft Q&A Platform.
Please add more information/details in the question, like which version on BizTalk, which CU you have installed, any change implement recently,..
With the error description, it seems like the old bug that was identified long time back and Microsoft has already given a fix of that. If you are using old BizTalk server then please check the below thread, hope this can help you.
Regards,
Kamlesh Kumar
BizTalk Techie
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