A Microsoft desktop and app virtualization service that runs on Azure. Previously known as Windows Virtual Desktop.
Good day,
I encountered a similar issue with VSTO-based Excel add-ins such as OpenText ALM and SAP Analysis for Microsoft Office on non-persistent virtual machines using FSLogix.
The root cause was traced to the Redirections.xml configuration, which included the following exclusion:
AppData\Local\assembly
This exclusion prevented the necessary .NET assemblies from being persisted in the user's FSLogix profile container, causing the add-ins to function correctly during the initial login but become disabled on subsequent logins.
To resolve the issue, I removed the above exclusion from the Redirections.xml file. After doing so, all VSTO add-ins continued to work properly across user sessions.
If you're experiencing similar behavior, please check your FSLogix configuration and remove the AppData\Local\assembly path from exclusions.