Hi Dionna,
Thanks for the updated information.
Have you checked the other options in my first post and could you let us know the outcome?
1.Disable preview pane in File Explorer.
2.Is there any files in this folder
C:\Users<username>\AppData\Roaming\Microsoft\Excel\XLSTART?
Meanwhile, please try opening Excel and go to File tab->options->Advanced->General and make sure
Ignore other applications that use Dynamic Data Exchange (DDE).
If it opens another blank window when you double-clicking on a file from File Explorer after trying the above, we want to confirm some information for troubleshooting:
1.A screenshot of "2016 Excel opens two windows when opening file".
2.Does this happen previously? If not, did you make any changes to your computer or Office before the sudden change?
3.A full screenshot of your Excel product information page from File tab->Account.
Regards,
Joanne