Hi Charles
Yes, you need to delete all partitions on the system drive, until you have just 1 unallocated space
If you have another drive in your PC, please make sure not to touch any partition on that drive also make sure not to delete the partition on the installation media . . .
So look for the drive with the OS/Primary
If that is Drive 0, then select each and every partition on that drive and delete it, if you are prompted not do delete a partition on that drive, go ahead and delete it anyway . . .
You should then end up with just 1 unallocated space, select that and click Next to install Windows
if there is any partition on that drive that will not delete, please provide the exact error you are seeing . . .