Hi @Pepe,
Welcome to Microsoft Q&A!
Do you mean that the Windows Defender is blocking your VS2022 from running? Or you are unable to open the C# application in VS2022? If you have any error messages or warnings, please share them with us.
Please ensure that you have necessary permissions to system-level files or drivers, and run VS as administrator.
You can try to add your VS process or source folder to the Excluded items in Windows Defender settings:
Settings > Windows Security > Virus & threat protection > Manage settings > Exclusions > Add or remove exclusions
Besides, the issue is more related to Windows Defender. You can also report it on Microsoft Defender forum. Thanks for your understanding!
Sincerely,
Anna
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