Hello Carl,
When I read about your Office shortcuts suddenly becoming unresponsive I understand how disruptive and confusing this can feel especially when everything worked fine the day before. It’s frustrating when something as simple as opening Word or Excel from your desktop or taskbar no longer reacts to a double‑click and it’s completely reasonable to want a clear explanation and a dependable fix. Issues like this often occur when Windows system components connected to your file associations or application links encounter small errors in the background which can cause shortcuts to stop launching even though the apps themselves are still installed.
Aside from the initial steps about clearing icon cache, re‑registering Shell Experience Host and repairing Microsoft 365 another effective and updated solution involves refreshing your Windows File Explorer components and restoring shortcut integrity at the system level. Restarting File Explorer can help reset the underlying process that manages desktop shortcuts and repairing corrupted system files through the System File Checker command can restore essential Windows components that may prevent shortcuts from responding.
According to current troubleshooting resources running sfc /scannow from an elevated Command Prompt can repair key Windows files that impact shortcut behavior and this method is known to resolve cases where shortcuts appear normal but fail to launch applications. To try this approach you simply need to open Command Prompt as an administrator, run the scan, let Windows repair any detected issues, and then restart your device. Once those components are refreshed your Office shortcuts may start responding normally again without needing to recreate them manually.
Before we move forward can you tell me whether your Office apps open normally when launched directly from the Start menu instead of from the desktop or taskbar?
I hope this answer is helpful if you have further questions feel free to reply back
Regards,
Marcelo