Is Defender saying malware or are the detections Potential Unwanted Programs/Apps (PUPs/PUAs)?
If the latter, the most common reason for this is potentially unwanted app blocking is turned on in Reputation-based protection found under Windows Security > App & browser control > Reputation-based protection settings.
If the detections are indicated as malware and you believe Microsoft Defender is detecting a legitimate file as a threat it may just be a false positive, then you should submit the file for malware analysis to Microsoft Research and Response team analysis.