Can they see those appointments in OWA?
Run Search-Mailbox for them to check if the items exist.
Also, check the retention policy assigned to them, the Default Policy Tag applies to all items in mailbox without a tag, which might be the cause.
If the tag is set to "Delete and allow recovery", you can try finding the items in Recoverable Items folder .
Besides, to check the retention dates for existing items, use MFC Mapi and follow this blog: https://answers.microsoft.com/en-us/msoffice/forum/msoffice_o365admin-mso_exchon-mso_o365b/how-and-what-to-check-when-your-emails-are-not/e9087576-fe91-4809-87fc-fff8cbb17c6a
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