The administrator account show NOT be mailbox-enabled, so yes ok to disable it.
ITs not used for NDRs or anything by default.
The postmaster@yourdomain.com email address can be associated with any shared mailbox. that is different from the built-in administrator account for the windows domain.
NDRs are generated by the system, not the administrator ;
https://learn.microsoft.com/en-us/exchange/recipients/recipients?view=exchserver-2019#microsoft-exchange-recipient