@LHocker Thanks for posting your query here!
Yes, host cache is not supported on premium disk 4TB or larger. It does ask you to select the cache, but when you save it, within no time it fails with the error "only disk caching type "none" is supported for disks above 4095GB.
You can go ahead and create a disk with 4095GB, however, P40 & P50 both support the same IOPS & throughput.
Kindly let us know if the above helps or you need further assistance on this issue.
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