Yes I believe so:
Renew Microsoft Exchange Certificate in Edge Server Exchange 2016
We will be renewing Microsoft Exchange Certificate in Edge Server.
Do we still need to resync Edge Subscription after the renewal?
There's also an existing 3rd-party SSL certificate.
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Cecilia Qin-MSFT 305 Reputation points Microsoft Vendor
2024-05-10T07:44:04.2633333+00:00 Hi,
If you renew or replace a certificate that was issued by a CA on a subscribed Edge Transport server, you need to remove the old certificate, and then delete and recreate the Edge Subscription. For more information, see Renew an Exchange Server certificate (https://learn.microsoft.com/en-us/exchange/architecture/client-access/renew-certificates?view=exchserver-2019#:%7E:text=If%20you%20renew%20or%20replace%20a%20certificate%20that%20was%20issued%20by%20a%20CA%20on%20a%20subscribed%20Edge%20Transport%20server%2C%20you%20need%20to%20remove%20the%20old%20certificate%2C%20and%20then%20delete%20and%20recreate%20the%20Edge%20Subscription.%20For%20more%20information%2C%20see%20Edge%20Subscription%20process) and Edge Subscription process(https://learn.microsoft.com/en-us/exchange/architecture/edge-transport-servers/edge-subscriptions?view=exchserver-2019#edge-subscription-process).