A family of Microsoft spreadsheet software with tools for analyzing, charting, and communicating data
Dear Josh Blunck,
Good day! Thank you for posting to the Microsoft Community. We are happy to assist you.
We’re truly sorry to hear that users are facing issues accessing Microsoft Office apps on the 2019 RDS server. We understand the frustration and inconvenience this has caused, especially after you've already tried reinstalling Office and modifying the registry. We genuinely appreciate the efforts you've made and sincerely apologize for any disruption this issue has brought to your work.
Considering that the issue occurs with new profiles while old profiles work as expected, it seems that the problem might be related to the server environment. To get the fastest and best assistance, we sincerely recommend posting your concern to the specific channel: Microsoft Q&A with Windows Sever tag. Members and engineers over there are proficient in Windows Server and Office issues and can address your query effectively and accurately.
Please accept our sincere apologies for not being able to resolve the problem directly and for redirecting you to a different community. The members in this category primarily focus on general Microsoft 365 and Office concerns and may have limited knowledge of Windows Server environment. We regret any inconvenience this may cause.
Once again, we apologize for the inconvenience this has caused. We appreciate your patience, understanding, and cooperation. Thank you for your time.
Hope you stay safe and healthy.
Sincerely,
Rhoda | Microsoft Community Moderator