Hello
Thank you for your question and reaching out. I can understand you are having issues related to iSCSI disks.
As you have MPIO which means there should be two or more paths to Storage or NAS for failover in that case you should lose iSCSI disks or connections.
Please check from switch or network side if there is any Drops or Latency in network of Storage connections.
Please also check iSCSI event logs in Event viewer and Storage logs for further clue .
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