Hi @sudarshan patil ,
Welcome to Microsoft Q&A!
If your operating system meets the system requirement for the .NET Framework versions 4.0-4.8.1, I suppose you can use .NET Framework from .NET Framework 4.0 to 4.8.1 in Visual Studio 2019.
It is noted that some .NET Framework versions are out of support, such as .NET Framework 4.0, 4.5, 4.5.1, 4.5.2, 4.6, 4.6.1. You can view it here.
For .NET Framework 4.8.1, it is included in VS2022 (version 17.3 or later). if you have VS2022 installed, you can install it via Visual Studio Installer > Modify > Individual components.
Or you can separately install it from the download site.
After installing, you can use it in VS2019.
Sincerely,
Anna
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