Hi @Justin Cooley ,
Welcome to Microsoft Q&A!
The Debug profile determines how to start debugging the application. You can right click on your Project Properties > navigate to “Debug” > create a debug profile by specifying various properties.
About the error message, please launch your VS2019 as administrator and create a new project to check if it persists or not.
Besides, you can try to change the Target framework by right-clicking on your Project Properties > Application.
Meanwhile, please delete the .vs and bin folder in your project folder, then, rebuild your project.
Sincerely,
Anna
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