Hi,
yes it is possible to configure a single or SAN based certificate to the RDP servers , please follow the process and requirements here. dn781533(v=ws.11).
In short the certificates you deploy need to have a subject name or subject alternate name that matches the name of the server that the user is connecting to. For example, for Publishing, the certificate needs to contain the names of all the RDSH servers in the collection. The certificate for RDWeb needs to contain the FQDN or the URL, based on the name the users connect to.
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