It may be that the debounce interval is too short, and what would happen is that the value is reset when the search function is activated. Have you tried increasing the value to DebounceInterval="1000" or more?
<MudAutocomplete T="ItemResponse"
Label="AutoComplete"
SearchFunc="@OnComboSearch"
Value="selecteditemResponse"
ValueChanged="OnComboValueChanged"
ResetValueOnEmptyText="true"
DebounceInterval="1000" />
Regards,