I echo your problem and frustration, but I finally found a solution that hopefully will help you, too.
Go to: GitHub - lostindark/DriverStoreExplorer: Driver Store Explorer [RAPR]
Read about DRIVER STORE EXPLORER and then scroll down to download the RAPR.exe file: https://github.com/lostindark/DriverStoreExplorer/releases/latest
It allowed me to scan my C:\Windows\System32\DriverStore folder to identify all the Brother related files and get rid of most of them. Then I rebooted my PC and successfully turned-on Core Isolation. I rebooted again to confirm Windows Security was all OK, and then reloaded my Brother applications and drivers for trouble-free operation of my Brother printers and scanner.
I'm no computer expert so don't ask me how it works. Good luck to you!