Through your description, I understand that you are experiencing the problem of missing emails or severe delays.
There are many reasons for the issue, such as transfer rules, email restrictions, and many more.
Can you provide more information so I can do further troubleshooting:
- Where do the delayed emails come from? Is it from a different domain?
- Are emails that are delayed delivered in Exchange?
- Do you have a spam detection policy set up?Can you check the email headers to identify the specific server where the problem occurred?
- Considering that you mentioned to Cisco Ironport, you can try disabling it and see if there is still lag.
Additional specific information can be found here Find and fix email delivery issues as a Microsoft 365 for business admin - Exchange | Microsoft Learn
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