Just login in safe mode. (restart computer while booting push f8). Select safe mode. login as the Administrator (or local admin account). In file explorer unhide the folders. File Explorer Menu -> Organize -> Folder and Search options -> Click View Tab
check Don' tshow hidden files, ..
uncheck hide empty drives
uncheck hide protected operating system files
click apply and ok.
Then using the file explorer delete the unused folders under users.
Careful not to delete active profiles!
Just fyi you should always try to delete the user profiles by using the system properties windows
the choose user profiles. From there you can delete the user profiles as a whole. this gets rid of registry entries and folders too. A lot cleaner.
but I understand the issues from this appdata roaming folder. Windows is not perfect.