This is not a Scroll Lock issue.
I am running Microsoft Office 365. I open an existing Excel file which has an existing chart object on the worksheet. I copy-paste special a new series from that worksheet into that chart. I then manually change the definition of that series (or any of the original series in the chart) in the formula bar without first de-selecting the chart (by clicking on a worksheet cell) and re-selecting it. When I then de-select the chart and select a cell on the worksheet, the arrow keys become disabled and the only way I can re-enable them is to close the file and reopen it.
Again, this is not a Scroll Lock issue - Scroll Lock is off. The arrow keys do nothing, they do not move the active cell nor do they scroll the worksheet. It doesn't happen if before modifying the series I first de-select the chart and re-select it.
This is, understandably, a fairly esoteric edge case, but I've been using Excel for years and this seems to have started only with Microsoft 365 so I'm fighting very ingrained habits. I've experienced this on different laptops working for different companies.
Mike