> 1. Remove the folder in %LocalAppData%\Packages\Microsoft.MicrosoftEdge_8wekyb3d8bbwe
This was very poor advice. Please don't give people this advice in the future. After completing this step Edge would no longer start. I would get the splash screen, which would disappear, and then nothing.
I eventually restored Edge following instructions here:
http://www.intowindows.com/how-to-reinstall-microsoft-edge-in-windows-10/
Anyway, in for a penny... here is the rest
> 2. Click three dots at the right corner of Edge > Settings > Clear Browse Data, choose what to clear part
I opened edge, went to Edge > Settings > Clear Browser Data, select "show more" and ticked every box, and then Clear.
I then retried the "Edit in Word" and see the same problem (as described in the original description)
> you still can't open in Word, please confirm the following information:
> 1. Try to open the PowerPoint or Excel documents in client application in Edge and share the result with us.
The "Edit in PowerPoint" action in PowerPoint online appears to work correctly, and opens PowerPoint on my PC with the presentation.
The "Edit in Excel" action in Excel online appears to work correctly, and opens Excel on my pc with the spreadsheet.
> 2. When does this behavior occurs?
I may not understand this question --- I think this is covered in the original description, but here are some screenshots of the action I'm taking in Word Online. The problem occurs both in Reading view and Editing view. For Reading view the problem occurs
regardless of whether Accessibility Mode is on or off (for some reason it defaults to on, which is a separate issue I'm having)

