A family of Microsoft word processing software products for creating web, email, and print documents.
When Word "struggles" with a large document, it isn't the number of pages that's important.
One main factor is the size of the file in bytes. The article on Word's limitations (https://docs.microsoft.com/en-us/office/troubleshoot/word/operating-parameter-limitation) says that the text is limited to 32 megabytes, not including graphics; the largest file that Word can open is 512 MB. Long before those limits are reached, though, Word slows down significantly, and the point at which that happens depends mostly on the amount of physical memory in your computer and on what other programs are running at the same time.
It's advisable to use a separate graphics program to reduce each picture to the final display size and resolution, to minimize its file size, before inserting it into the Word document. Otherwise, the original file size determines how much memory it'll occupy when you load the document, and Word will have to use CPU to recompute the picture's data to match the display size each time.
Another main factor is the complexity of the document. You can minimize this by doing all (or almost all) formatting with styles and not with directly applied formatting; by using "in line with text" wrapping for all graphics; and by not using any nested tables (that is, a table inside a cell of another table).
One thing that may help, if you update to Word 2019, is that new installations now default to 64-bit programs (your Word 2010 is probably 32-bit). That should make memory manipulation by Word and Windows somewhat faster. Other than that, though, most of Word's internal code is largely the same except for the new features.
Because your document is so large, having at least one reliable backup is crucial. Word's tools for timely backups have improved over the years but are still inadequate for critical projects. I recommend that you set up the Windows 10 File History feature (https://support.microsoft.com/en-us/help/17143/windows-10-back-up-your-files) to maintain multiple versions of the document. Although the article says the feature needs an external drive or a network drive, it will also work with a drive that's internal to your computer as long as it isn't the same one as the drive that holds the working document. In addition, you can manually back up the file to a cloud service such as OneDrive or Dropbox -- but don't store the working copy in the cloud-linked folder, which would slow down Word.