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Office 365 "The operating system is not presently configured to run this application." Windows 10

Anonymous
2020-02-13T15:37:08+00:00

Hi all, 

I had checked a bunch on google related to this, but other than non-scientific old Youtube videos to fix the issue, couldn't find much, and they didn't help either. 

As of now, this issue is persistent on 2 of my machines, using different activation of Windows, one is Windows 10 Education and the other is Windows 10 Pro. Both of these machines are sort of up to date with updates.

I logged on to my Office account to download and install on the systems, but both the system show the same behavior post install: not launching any Office 365 apps, and with some apps, it shows the error: "The operating system is not presently configured to run this application."

For troubleshooting, I've tried to reinstall/change/modify/repair Office with no effect. Ran the product in various compatibility modes, no effect. Downloaded and ran Microsoft Support and Recovery Assistant, tried to reinstall windows and try again, with no change in the situation. 

It's frustrating to see a Microsoft product: Office365 not being able to run on an up to date Microsoft product: Windows 10, when some of these apps are absolutely essential for education and content creation and much more.

Any and all help is appreciated, please let me know if you have any follow up questions, or need any details. 

Thanks, 

Best,

Mehul

Microsoft 365 and Office | Install, redeem, activate | For home | Windows

Locked Question. This question was migrated from the Microsoft Support Community. You can vote on whether it's helpful, but you can't add comments or replies or follow the question.

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  1. Anonymous
    2020-02-25T06:49:10+00:00

    Hi Mehultw,

    You can post back anytime when you free or need further help. I will still keep monitoring this case for you.

    In the meantime, I would like to make a summary on this issue. This will also help other community members to find solution much easier of they come across the same situation:

    Issue Description**:**

    Unable to launch Office 365 application on machines and get error message” "The operating system is not presently configured to run this application."

    Environment**:**

    Office 365 on windows10.

    Suggestion**:**

    1. check and make sure that you do not have multiple installations of Office 365 proplus. Go to Programs and Features from Control Panel (Control Panel > Programs and/or Programs and Features). Removed unwanted multiple versions of Office 365.

    1. Uninstall Office 365 completely by using Microsoft Support and Recovery Assistant (SaRA). It can help you automatically diagnose and fix a range of Outlook problems. You will need to download the application to your local computer, sign in with your work or school account and select the issue you want help with.

    3.Turn compatibility mode off on Windows 10.

    a.From the Start screen, select an Office application that causes the error.

    b.Right-click on the selected Office application and tap or click Open file location.

    c.The Windows Explorer is opened with the selected Office application highlighted.

    d.Right-click the Office application icon that is causing the error and tap or click Properties.

    e.Tap or click the Compatibility tab.

    f.Uncheck Run this program in compatibility mode and tap or click OK.

    Best Regards,

    Waqas Muhammad

    3 people found this answer helpful.
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  1. Anonymous
    2020-02-21T08:42:39+00:00

    Hi Mehultw,

    First of all, sorry for late reply. We appreciate that you spent your precious time doing those tests. However, we appreciate your time and understanding.

    As per your description you are unable to launch Office 365 application on your two different machines. We understand you tried a lot of the troubleshooting steps e.g. reinstall/change/modify/repair Office and Microsoft Support and Recovery Assistant tool. But in order for further investigation on this issue, we might need to double confirm with you some steps you might already tried.

    According to error message you provided, please try the following steps and see the result. 1.Navigate to Programs and Features from Control Panel (Control Panel > Programs and/or Programs and Features).

    2.In Programs and Features check and make sure that you do not have multiple installations of Office 365 proplus.

    3.If found, then after checking the versions make sure to remove/uninstall other Office installations. Once you have removed unwanted multiple versions of Office make sure to repair the current Office 365 installation.

    3.Right-click on the Office 365 installation and click on Change > Online Repair.

    3.Once repaired make sure to restart your computer.

    Let’s turn compatibility mode off on Windows 10 and verify the result.

    1.From the Start screen, select an Office application that causes the error.

    2.Right-click on the selected Office application and tap or click Open file location.

    3.The Windows Explorer is opened with the selected Office application highlighted.

    4.Right-click the Office application icon that is causing the error and tap or click Properties.

    5.Tap or click the Compatibility tab.

    6.Uncheck Run this program in compatibility mode and tap or click OK.

    If issue still persist, we need to collect following information:

    1.Screenshot of Office version (Click File>select Account).

    1. Screenshot of error message.

    3.The detailed version number of your OS(Click Win+R>type CMD>OK

    1. Confirm you are using 32bit Windows but installed the 64bit office?

    We greatly appreciate your understanding and time.

    Best Regards,

    Waqas Muhammad

    2 people found this answer helpful.
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  2. Anonymous
    2020-02-24T07:41:36+00:00

    Hi Mehultw,

    Are you able to launch Office 365 application on your machines now? Please share the above information at your convenience.  We will try our best to provide support for you.

    Best Regards,

    Waqas Muhammad

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  3. Anonymous
    2020-02-14T14:02:48+00:00

    Totally irrelevant, as Outlook doesn't launch, the whole issue is that apps don't launch. Please read the whole issue and then try and provide a resolution.

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  4. Anonymous
    2020-02-13T15:41:23+00:00

    This isn't a fix, just a possible workaround:

    Error: The operating system is not presently configured to run this application.

    This issue can occur with certain actions:

    ·    Using Send To / Mail To.

    ·    May occur when trying to open the Mail Applet in the control panel.

    ·    When using the Outlook Object Model attempting to either attach to or invoke a new Outlook session from a stand-alone program.

    ·    RuntimeBroker.exe process may cause the error.

    Workaround: In some cases you may need to use Task Manager to end the task or you can restart Outlook.

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