I have discovered an issue when saving a document that causes the document to become corrupt, which means it can no longer be opened.
This issue occurs in the latest version of Word (at the time of writing) in the Current Channel of Office 365.
The version number is 15225.20288 as can be seen below.

I have also reported this issue via Help > Feedback > I don't like something, and linked to this post so they can see screenshots and reproduction steps.
Overview
This seems like an error which has been experienced in past versions of Word but I can now recreate it consistently with the above version.
The actual error that occurs is best described in this post here:
https://answers.microsoft.com/en-us/msoffice/forum/all/error-the-name-in-the-end-tag-of-the-element-must/864fa11e-05f5-47ce-888c-253dada13e32
When saving the document it seems that word is creating malformed xml which causes the document to become corrupted.
Specifically here:

Other examples of this (or a similar issue) on this forum
https://answers.microsoft.com/en-us/msoffice/forum/all/the-name-in-the-end-tag-of-the-element-must-match/eb3e7989-397f-43a7-8f46-b1294ad18e2b
https://answers.microsoft.com/en-us/msoffice/forum/all/end-tag-error-in-word-document/4b594d00-b9a0-47cc-8d0e-d664c881b6c4
And an article for an older version of word
https://docs.microsoft.com/en-GB/office/troubleshoot/word/end-tag-error-when-open-docx
The above fix still works, but then the issue re-occurs when saving the document again.
Reproduction Steps
In order to test this issue I have created a sample document called Corruption Test.docx which can be found here:
https://www.dropbox.com/sh/l2kv7xvpybasjv1/AADIJ5XvuHZLWVz2MSow9FeMa?dl=0
This document is a standard blank word document to which I added 2 textboxes with the exact same anchor point, and then added a content control to one of the textboxes.
In the same folder is also a file called Corruption Test - Broken.docx which is an example of what happens to the document when the corruption occurs.
- Open Corruption Test.docx in Word.
- Put the cursor after the word TEXT here:

- Type some text
- Save the document (Ctrl+S or Ribbon Button)
- Delete the text you typed
- Save the document (Ctrl+S or Ribbon Button)
- Close the document
- Open the document
- The following error will be displayed

Please note that this error does not always occur the first time the above steps are followed, some times it is necessary to repeat the above steps until the issue occurs. The most it has taken me to get it to occur is 6 times.
This issue seems to be caused by the combination of 2 textboxes which share an anchor, and one of them having a content control in them. If I remove either of the textboxes, or the content control I cannot get the issue to occur.