Dear Robert Massart,
Good day! Thank you for posting to Microsoft Community. We are happy to help you
According to your description, we understand that you found splwow64.exe would pop up when running 64-bit Office applications, which you think may be related to the latest updates of Office.
Splwow64.exe is a Windows core system file which runs in the background services of your operating system Task Manager lists it as the “Printer driver host for 32-bit applications.” In other words, splwow64.exe allows 32-bit applications to connect with the 64-bit printer spooler service on x64 Windows builds. If you want to disable this process, you can refer to this thread first: Word 64bit wants to print under splwow64.exe - Microsoft Community
We also think this phenomenon is unreasonable, but I don't seem to have encountered the same phenomenon in our tests here, so I don't think it's necessarily the Office application updates that cause this phenomenon. Howver, to further reduce this phenomenon, we kindly recommended you can raise a service request in Microsoft 365 admin center, which the support there has the related permission and resource to help you check from the backend. At the same time, they can help you further analyze this phenomenon by helping you remotely obtain the activity logs of your application.
Sincerely,
Tin | Microsoft Community Moderator