Will office 365 professional version work on MacBook Air ? What are the compatibility issues here ?

Hi

My license is E3 and it definitely works on Mac.

The browser-based apps work the same on Mac and Windows.

Desktop apps that are Windows-only work only on Windows, but as Bob points out, you can install Parallels desktop and run them in a virtual machine, if needed.

Word, Excel, PowerPoint and Outlook are mostly the same Mac and Windows, but there are substantial differences when it comes to specific features. Windows apps lack the most basic element you would expect: Menu Bar. Anything that requires windows (COMM add-ins, Active-X, etc) won't work on Mac.

I use my Mac Office apps almost exclusively, but there are times I need to do things that only the Windows version has. Thankfully, that's only once or twice a month, for which Parallels works great for me.

The point also should be made that the only difference with Office 2021 Professional is the inclusion of Publisher & Access. Neither of them run on a Mac other than in a VM which supports the Windows OS. The core programs are identical to those provided in Mac Office 2021.

The difference to be aware of is that the Retail [perpetual] License packages have the same fixed feature set as when first published, whereas the Subscription License software has received & will continue to receive feature enhancements as they become available... The Retail package does not get anything but bug fixes & security updates..