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Hi, Sam King5
Thanks for posting in the community.
I realize you are confused about whether uninstalling a program on one computer will affect the data in your Documents folder, and I understand your feelings.
In the situation you describe, uninstalling the program itself will not directly affect the data in your Documents folder, especially for the data stored in the OneDrive sync folder.
- Uninstalling programs and data in folders
Typically, programs (such as VST plug-ins) will install their executable files and related system files to Program Files or other specialized folders, while user data (such as plug-in settings, configuration files, audio files, etc.) may be saved in Documents or other user folders. Uninstalling a program will only delete the directory where the installation files are located and related registry information, and will not affect the data in your Documents folder.
- OneDrive syncing
If your Documents folder (and the data in it) has been synced to your desktop computer via OneDrive, then these files will be synced between the two devices. Even if you uninstall some programs from your laptop, as long as the data of these programs is still saved in the Documents folder of OneDrive, they will continue to sync with the desktop computer.
I hope that clears up your confusion.
Best Regards, Zain.M - MSFT | Microsoft Community Support Specialist