Sadly no, this is not possible, the Microsoft mouse and keyboard sets are paired specifically with the USB transceiver they are provided with and it is not possible to use a Microsoft mouse or keyboard with a different USB transceiver, it is also not possible to get a replacement transceiver, Microsoft do not provide a method to do that.
Microsoft wireless mouse 5000
Can I synchronise a microsoft mouse 5000 of one set with another same set?
Windows for home | Windows 10 | Devices and drivers
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DaveM121 890.4K Reputation points Independent Advisor2026-04-27T06:15:31.9+00:00 -
AI answer
2026-04-27T05:41:43.5233333+00:00 The Microsoft Wireless Mouse 5000 uses its own matched transceiver (USB receiver) and is not listed among the devices supported by Microsoft Mouse and Keyboard Center for advanced configuration or pairing changes. The context does not provide any method to re-pair or synchronize a mouse from one set with the USB receiver from another set.
Based on the available information, there is no supported way described to synchronize a Microsoft Wireless Mouse 5000 from one combo with the receiver from another combo; each set is intended to be used as shipped.
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