Hello arwah abdalla,
Thank you for posting in Microsoft Community forum.
You can try to redirect these user folders to another network shared path using Group Policy, then block the C drive.
For more information about Folder Redirection using Group Policy
Folder Redirection using Group Policy on Windows Server | Microsoft Learn
I hope the information above is helpful.
If you have any question or concern, please feel free to let us know.
Best Regards,
Daisy Zhou