Hi Jim54,
Thank you for using the Community Forum for Vista.
Usually, this is a hardware issue.
If you are comfortable with the BIOS, you can take a look at your manual first and see if there are options in the USB settings to allow it to “wake” the computer.
Editing the BIOS can cause severe damage to your computer, proceed at you own risk.
Also, you should be able to tap the power button to wake up the machine.
I hope this helps, let us know!
Matt Hudson
Microsoft Answers Support Engineer
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