Hi,
1. Did you make any changes on the computer prior to this issue?
2. When exactly do you get this error message?
3. What is the exact error message?
Step 1: You may uninstall and reinstall iTunes and check.
Refer:
Removing and Reinstalling iTunes, QuickTime, and other software components for Windows XP
http://support.apple.com/kb/ht1925
Step 2: If the above step doesn’t help then I would suggest you to contact Apple support team.
Also refer the following article which might help you.
iTunes: "Error 42408" or "Error 42404" after upgrading to iTunes 9.0.3