Me? No
The best "safe cleaner" is CCleaner, even then be careful when you use the registry cleaner if you must.
Best place for drivers is not a cure all, so don't rely on one.
Learn your pc, if intel or amd, visit their sites regularly using their driver utility to check for updates.
Graphics? Basically every month.
Realtek? As above nearly every month.
If you get stuck download Driver View from Nirsoft (free) It will list your drivers, post it here or a link and I'll tell you what needs updating / you don't want anywhere near your pc (bsod's)