How do i Fix appcrash (Photoshop) in my Computre?

I'm trying to use a program call Photoshop CS5.1. Software is working fine and while saving it saying Adobe Photoshop CS5.1 has stopped working. What ever I have worked all I lose not even save at the time. I am here with given error showed as screen for your kind reference. Please have a look and advise me how to solve the issue.

Problem signature:

Problem Event Name:      APPCRASH

Application Name:            Photoshop.exe

Application Version:          12.1.0.0

Application Timestamp:   4d90cf71

Fault Module Name:         Photoshop.exe

Fault Module Version:      12.1.0.0

Fault Module Timestamp:                4d90cf71

  Exception Code:                c0000005

Exception Offset:               009528d3

OS Version:        6.1.7601.2.1.0.256.48

Locale ID:            16393

Additional Information 1: 0a9e

Additional Information 2: 0a9e372d3b4ad19135b953a78882e789

Additional Information 3: 0a9e

Additional Information 4: 0a9e372d3b4ad19135b953a78882e789

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