"the procedure entry point OpenVxDHandle could not be located in the dynamic link library KERNEL32.dll"

Hi,

1. When do you get this error message? Is this error occurs when you launch a specific program or randomly?
2. What are the steps that you have tried to fix the issue?
3. Have you installed any recent hardware or software prior to the issue?
4. Are you able to boot the computer to desktop?

Method 1:

Step 1: Safe mode

Boot your computer in safe mode and check for the issue.

To start your computer in Safe mode

http://windows.microsoft.com/en-us/windows-vista/start-your-computer-in-safe-mode

Step 2: Clean boot

If you do not face the issue in safe mode, then put your computer in clean boot and check for the issue.

How to troubleshoot a problem by performing a clean boot in Windows Vista or in Windows 7

http://support.microsoft.com/kb/929135

Note: Once you are done with clean boot, please follow step 7 in the article to put your computer back to normal startup.

Method 2:

Perform an SFC scan on your computer. Refer to the following link:

How to use the System File Checker tool to troubleshoot missing or corrupted system files on Windows Vista or on Windows 7

http://support.microsoft.com/kb/929833

Hope it helps.