Hi Kevin,
Thank you for posting your query in Microsoft Community.
- Did you make any changes prior to this issue?
This issue could be caused due to an issue with the touch driver or due to a hardware issue with the touch screen. Many Asus vivo tab users have reported the same issue. So, it appears to be an issue with the hardware. When I checked the Asus website, they have suggested the users who are facing this abnormal touch problem to contact the local ASUS service center and have advised not to use the built-in Windows calibration function. So, in this case, I suggest you to contact the manufacturer support as this seems to be a hardware issue. You can also refer to this article:
Hope this helps. Feel free to get back to us for any other Windows related queries in the future; we’d be happy to help.