Had the same question, and I too was waiting to update.
However, I updated another laptop to Windows 10 and I decided to try to install the n52te on it to answer the question.
I am happy to report that it seems to work. However, I haven't done extensive testing...
However I can attest that:
-The Vista driver installs properly
-The n52te is recognized and works as a keyboard (tried it in Notepad)
-The control panel runs and can update the onboard Synapse memory
What doesn't work:
-The control panel does not recognize the current keymap (non default). The n52te behaves as it did on my other PC. You have to redo your keymap manually.
I am satisfied enough by this testing to update my gaming PC.