Thanks for the suggestions Ankit,
The folders I am concerned about are data files for Windows Store applications that are stored in the folder %USERPROFILE%\AppData\Local\Packages{PackageId}. Modifying Windows System Protection does not remove the data for Windows Store applications. Similarly, Disk Cleanup has no effect on these folder sizes,
An investigation of the folder
%USERPROFILE%\AppData\Local\Packages\Microsoft.BingNews_8wekyb3d8bbwe
Showed total of 18 GB across 2 users on one PC and similarly large multi-gigabyte folders on others machines. One temporary solution is quite simple, uninstall and reinstall the Microsoft News application. The folder grows in size over time so you need to do this periodically
An investigation of the folder
%USERPROFILE%\AppData\Local\Packages\windows_ie_ac_001
Showed that there were some copies of large DVD ISO I downloaded several years ago in hidden folders. I simply deleted them with no apparent ill effects.
In both cases I would expect the Microsoft written applications to clean-up the disk space they use themselves rather than expect users to manually clean-up after them.
Regards, David