I also have gateway NV78 and I am having the same problem., but never down loaded from Itunes. Most of my down loading is Mods for The Elder Scrolls III, IV, and V. and Games from Steam.
Steam was not working properly and a big hassle tried uninstalling it and couldnt get all of it to uninstall ..got mad and deleted the rest. Then my hard drive went had Best Buy replace it, but the optiarc cd rom stopped working a little while after down loading a beta mod and removing steam. I dont no why Best Buy did not fix it. I live 40 miles from town and don't drive.. so i just had my son drop it off to fix hard drive and pick up a external hp rm475e. I have all the cds for my games but the Hp only reads morrowind. Oblivion and Skyrim it just keeps saying insert disk.,, the disk spins then slows down the repeats this over and over again
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I finally download steam and reinstalled hoping it word correct it self, for i am not very computer smart like you guys. Also downloaded EScrolls IV and V. they are working ok.,,but when I insert skyrim which has Steam built right in to game annd click add game and search drive E it says insert disk.
I was going through my Oblivion.ini it said searching for cd rom cant find cd rom . but said found archive of old oblivion cd.
I have just given up cant afford another 300.00 @ Best Buy.,,until I saw your post w/same computer and same problem. Oh also I have multi system like 32 & 64 bit & all kinds of windows versions. xp 2003 2008, Vista & Os etc. Hope you get a solution response so I can do try it to. SOMEOE PLEASE HAVE ANSWER.