AFAIK, there's no general method to determine how changes in the Registry are made, but if the value for this key is
cadca5fe-87d3-4b96-b7fb-a231484277cc
then it was created by your antivirus program to indicate that the antivirus program is compatible with the Microsoft patch that helps protect against the recently-announced Meltdown and Spectre bugs in Intel and other processors. See, e.g., https://support.microsoft.com/en-us/help/4056897/windows-7-update-kb4056897
More discussion here: How to Check and Update Windows Systems for the Meltdown and Spectre CPU Flaws