Don't think safe mode and clean boots will solve the issue. The constant writing to C:\Windows\System32\SleepStudy\UserNotPresentSession.etl now occurs intermittently. The first 20 boot cycles or so after my initial Win 10 install, it was there every time, forcing my disk activity to 100% for the entire session. I have since found and followed the recommendations in the following article ...
which suggests:
- use perfmon to Stop the UserNotPresentTraceSession
- mark files in C:\Windows\System32\SleepStudy read only
- reboot
Now it only appears once in a while after a reboot, and when it does my disk activity runs at 100% for the entire session. I'm not sure what causes it, but I'm pretty sure it's related to something that happened in the previous session. As the poster for the above article states, Win 10 has a few remaining bugs in it's sleep study.