Open Start, type: file explorer options
Hit Enter
Under the General tab, click in the Open File Explorer to then choose "This PC".
Try WinKey + E now. If it opens fine, then the problem is with Quick access cache, which can be cleared by deleting *.automaticDestinations-ms from the following directory, using Command Prompt.
%AppData%\Microsoft\Windows\Recent\AutomaticDestinations
Press Windows key + R
Type: %AppData%
Hit Enter
Then navigate to that folder.
Could be an issue with your display driver.
uninstall your display driver then restart
Boot to the Windows 10 desktop
Press Windows key + X
Click Device Manager
Expand Display adapters
Right click the current display adapter
Click Uninstall
Exit Device Manager
Restart