Hi Isabel. I'm Greg, an installation specialist and 8 year Windows MVP, here to help you.
For best Windows performance and least issues I would run only built-in Defender which gives adequate protection, least issues, and is from Microsoft who knows how to protect their OS best. If you want the best on-demand scanners install and run Malwarebytes and AdwCleaner free scanners.
But if you insist then go to Settings > Update & Security > Windows Defender > Open Security Center > Virus and Threat Protection Settings, turn off Real Time Protection. This should allow installing the 3rd party anti-virus, but expect issues and don't be surprised when they happen.
I hope this helps. Feel free to ask back any questions and let us know how it goes. I will keep working with you until it's resolved.
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