Can I work around the lack of updated driver?
Unfortunately not. Only Microtek has the proprietary knowledge of its scanners needed to write a driver. That knowledge is also Microtek's intellectual property that one else has the right to use.
With nothing to lose, if the 4800 has a more recent successor with a driver for Windows 10 or even Win8 or Win7, you could give it a shot.
One thing I would advise against is a driver that you obtain from a third party on the internet. It won't be from Microtek so you won't know what you're really getting.