Hi Gabe
My name is Andre Da Costa; an Independent Consultant, Windows Insider MVP and Windows & Devices for IT MVP. I'm here to help you with your problem.
What is the make and model of the motherboard?
Press Windows key + X
Click Device Manager
Expand Universal Serial Bus controllers at the bottom
Right click each entry then click uninstall
Exit then restart
Windows 10 will then redetect them.
Check if they then work.
You might need to update your BIOS and chipset drivers.