Disable Windows 10 keyboard shortcuts

Hi, this is Rivgil. An independent advisor. I'll be glad to help. You may follow these steps.

On your keyboard, press and hold the buttons “Windows” and “R” to open the run box.
Type in the run box “Gpedit.msc”.
Hit “Enter” on the keyboard.
You will get a message from User Account Control and you will have to left click on “Yes”.
You will have to left click in the left panel on “User Configuration”.
Under the “User Configuration” file left click on “Administrative templates”.
Under “Administrative templates” left click on “Windows Components".
Now after you got to “File Explorer” you should have in the right panel a feature that says “Turn Off Windows + X hotkeys”.
Double left click or tap the “Turn off Windows + X hotkeys”. A window should pop up after you selected the option above and you will have the option to disable the feature.
Left click on the “Apply” button you have in the lower side of that window.
Left click on the “OK” button you have in the lower side of the window.
You will have to close the Group policy editor window and reboot the Windows 10 device.
After the reboot check if you have the same keyboard shortcuts disabled.

Hope that helps!

Thanks for the reply.  Your suggestion followed a different route to what I'd already tried.  When I got to "turn off Windows key hotkeys" I found it had already been enabled.  (Note the double negative - enabling the feature is supposed to disable the hotkeys.)

{Win + I} still opens Windows Settings.

There are some key combinations that cannot be disabled (as far as I know) they are a built in feature and have been present in many versions of windows.

I just now found that "shift" will work as a combination key for macro activation.  (I thought the activations didn't distinguish between upper and lower case letters, but they do.)  So while "Win" was more versatile, "shift" will do and I'll stop trying to do the impossible with the "Win" key.  Thanks for the help!

Thanks Rivgil and neilpzz.

It seems to be one extreme or the other!  I tried Rivgil's link to 3 methods to disable the Windows key.  It says "After testing, the first two methods seem to disable only these keyboard shortcuts: Windows + D, Windows + R, Windows + S, Windows + A".  I tried the 3rd method but unfortunately that eliminates the Windows key completely - making it as if it didn't exist.

The reason I'm going through all this is that I've written many macros (using Macro Express Pro) which I've set to be activated by a Win-ctrl-X sequence (for "global" macros) and a Win-alt-X sequence (for macros that run only when certain programs have the focus), where "X" stands for any alphabetic character.  These macros all activated fine under Windows 7 but having switched to Windows 10 I find they no longer do.  I'd change the activations to C-ctrl-X and C-alt-X, where "C" is a key that can be used in combination with another key.  But I know of no such key, other than ctrl, alt, and (under Windows 7) "Windows".  ("shift" doesn't work.)

Any suggestions for a work-around would be greatly appreciated!