Hi Angelo,
Thanks for the question!
One Device security is Core isolation that provides virtualization-based security features to protect core parts of your device.
Memory integrity is a security feature of Core isolation that prevents attacks from inserting malicious code into high-security processes.
So the question is...will this slow down your system?
The answer would be - yes; but, with caveats. Having a virus scanner slows down your system, installing a lot of software on your computer slows it down - its really about the cost-benefit analysis. As this would protect you from someone inserting malicious code, I would say keep it on. It's just another layer of protection and the process should not overrun your memory too much.