32bit applications will load and install on a 64bit machine without an emulator. The problem can come in old applications that do not support the newer operating system for various reasons. Also, some older games do require an emulator.
If you right-click on the program, you need to make sure it is not a shortcut to the program. if it is a shortcut you can right click and choose "open file location". Then right click the program, then click properties then go to the compatibility tab.
Then check the box next to "Run this program in compatibility mode for:". Then choose which OS version to run it in compatibility mode for. You may also need to change the other settings below this depending on the application.
What application are you trying to run? What error is it giving you?